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Invitrogen
Gliadin Monoclonal Antibody (14D5)
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产品信息
HYB 314-01-02
产品规格
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
14D5
抗原
Synthetic peptide corresponding to residues K(58) L Q P F P Q P E L P Y P Q P Q(73) of gliadin peptide.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.05 mg/mL
规格
210 µg
保存条件
4°C, store in dark
运输条件
Wet ice
RRID
产品详细信息
HYB 314-01-02 detects the Gliadin peptide in wheat samples. The immunogen corresponds to a deamidated form of a region that includes the T-cell epitopes, including the immunodominant PQPQLPY region and two PXPQP motifs associated with binding to IgA from patients with celiac disease. It reacts specifically with the deamidated peptide when coated directly in an immunoplate.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
靶标信息
Celiac disease is associated with a CD4+ T-cell response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC molecules. These epitopes are present in a 33-mer peptide of wheat alpha-gliadin, residues 56-88, which is resistant to digestion and forms a substrate for tissue transglutaminase (TG2), generating the glutamic acid residues essential for binding to HLA-DQ2. Complete homology exists between residues 63-73, 70-80 and 77-87 of wheat alpha gliadin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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